Contents of this article
- 1. Is Henan Vero Cells from Beijing Biotech or Sinovac?
- 2.
- 3. What is Vero Cell? Sinovac or Biotech?
- 4. Are vero moda and only the same brand?
Is Henan Vero Cell from Beijing Biotech or Sinovac?
It is from Beijing Sinovac Zhongwei.
Vero cells, what is Sinovac or Biotech?
what are vero cells
What are vero cells? Nowadays, many people are very interested in Vero cells. Therefore, some people found that there is a term on the vaccine box: vero cells. Everyone is curious about what it is. Let me give you a brief understanding of what vero cells are. What.
What are vero cells1
The novel coronavirus pneumonia inactivated vaccine (vero cell) is a novel coronavirus vaccine suitable for preventing diseases caused by novel coronavirus infection (COVID-19). Among them, vero cells are cells isolated and cultured from the kidney tissue of healthy African green monkeys. They are currently the most widely used passage cells in biological laboratories. They have three advantages: the first is that they are easy to culture, and the second is that they are stable in passage. The third has the ability to divide indefinitely and is therefore used in the production of many vaccines.
How many injections of the new coronavirus vaccine vero cells should be given?
2 two stitches. There are currently three main types of vaccines: inactivated new coronavirus vaccine (Vero cells), recombinant new coronavirus vaccine (type 5 adenovirus vector) and recombinant new coronavirus vaccine (CHO cells). Among them, for the new coronavirus inactivated vaccine (Vero cells), this vaccine requires a total of two shots. The recommended interval between the two shots is ≥ 3 weeks, and the total should be completed within 8 weeks. However, it should be noted that even There is no need to re-vacculate after 8 weeks, as long as the unvaccinated doses are filled up.
The difference between cho cells and vero cells in the new coronavirus vaccine
The new coronavirus vaccine cho cells are recombinant new coronavirus vaccines (CHO cells). They express the most effective antigen components in cells in vitro through genetic engineering. The production process is relatively safe and easy to produce on a large scale. It needs to be Refrigerated and low temperature transportation at 2-8 degrees Celsius. Vero cells, the new coronavirus inactivated vaccine (Vero cells), are actually vaccines prepared by inactivating cultured and amplified live viruses through physical and chemical methods and then undergoing a series of purification techniques. Its main features are strong immune response and good It is safe and stable, easy to transport, and more convenient to use in remote areas. It uses two shots of immunity.
What are vero cells 2
Vero cells (African green monkey kidney cells) were officially isolated from the kidneys of African green monkeys by Japanese scholars Yasumura and Kawakita in 1962. They were first used to produce aneuploid attachment-dependent cells for the production of human biological products, and established the cell lines and cell banks of different generations. Prior to this, only primary cells or diploid cells were allowed for the research and production of biological products.
The diploid cell line has a limited number of passages. When it reaches a certain number of passages, it will age and undergo apoptosis, making the production process unable to be put into large-scale production. For a long time, people have rarely considered and applied passaged cells as a substrate for the production of biological products. Due to limited detection methods, the research on their tumorigenicity and exogenous contamination and other characteristics was unclear. It was not until 1987 that WHO officially approved passaged cells. Cell lines serve as substrates for biologics production.
After Vero cells were approved for the production of human vaccines, the first human vaccine produced was the inactivated polio vaccine (IPV) produced by Barrett et al. Later, Vero cells were used for rabies virus vaccine and oral poliovirus vaccine ( OPV) and other human vaccines are produced. Vero cells have been used in the production of viral vaccines for 30 years, especially rabies and polio vaccines.
The Vero cell line is widely used in the production of human vaccines based on its unique properties. Vero cells cannot express the antiviral protein interferon due to their inherent genetic defects. Barrett et al. [1] tried to infect Vero cells with Newcastle disease virus, Sendai virus, and rubella virus to produce interferon. The results showed that Vero cells could not express and secrete interferon protein. However, when the experiment was repeated using BSC-1 cells and other primate cells under the same conditions, these cell lines expressed and secreted large amounts of interferon proteins. There are reports in the literature that Vero cells may have defects in β and α genes and cannot express interferon proteins. The broad susceptibility characteristics of Vero cells have promoted the development of vaccine production using Vero cells.
In addition to the above advantages, Vero cells also have the following advantages compared with primary cell lines and diploid cell lines for the production of biological products:
1. Convenient source, easy to establish and store cell bank, can be continuously passaged, and has fast growth rate;
2. Vero cells have stable genetic traits, low probability of malignancy, no external contamination, and good biosafety characteristics;
3. Vero cells are sensitive to a variety of viruses and produce viruses with high titers;
4. Vero cells do not have high requirements for culture conditions. They can adhere well to the surface of microcarriers and grow easily, and can be easily scaled up and cultured in bioreactors.
Are vero moda and only the same brand?
Vero
Moda is considered an international brand
ONLY is simply a Chinese company registering a trademark abroad and then selling it back to China. There are basically no sales stores for them abroad. Judging from the workmanship of their products, they should be produced in Fujian and Zhejiang.
The above is all about where vero is produced, whether Henan vero cells are from Beijing Biotech or Sinovac, and related content about verona. I hope it can help you.